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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK1
All Species:
25.76
Human Site:
S498
Identified Species:
70.83
UniProt:
Q9BQI3
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BQI3
NP_001127807.1
630
71106
S498
V
G
T
C
L
Y
A
S
P
E
Q
L
E
G
S
Chimpanzee
Pan troglodytes
XP_518962
630
71034
R498
A
H
V
T
A
W
V
R
P
G
L
L
R
G
A
Rhesus Macaque
Macaca mulatta
XP_001089983
630
71146
S498
V
G
T
C
L
Y
A
S
P
E
Q
L
E
G
S
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2R9
619
69669
S495
V
G
T
C
L
Y
A
S
P
E
Q
L
E
G
S
Rat
Rattus norvegicus
Q63185
620
69580
S496
V
G
T
C
L
Y
A
S
P
E
Q
L
E
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507688
626
71317
S496
V
G
T
S
L
Y
A
S
P
E
Q
L
Q
G
S
Chicken
Gallus gallus
NP_989979
635
72216
S505
V
G
T
C
L
Y
A
S
P
E
Q
L
Q
G
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001071035
621
70025
A492
V
G
T
F
V
Y
A
A
P
E
Q
L
E
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001123105
822
95490
S699
V
G
T
Q
L
Y
M
S
P
E
Q
M
N
G
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.4
94.7
N.A.
N.A.
81.5
80.9
N.A.
63.8
53.2
N.A.
42.3
N.A.
N.A.
21
N.A.
N.A.
Protein Similarity:
100
96.3
96.9
N.A.
N.A.
89.2
88.5
N.A.
76
67.4
N.A.
58
N.A.
N.A.
36.9
N.A.
N.A.
P-Site Identity:
100
20
100
N.A.
N.A.
100
100
N.A.
86.6
93.3
N.A.
80
N.A.
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
100
33.3
100
N.A.
N.A.
100
100
N.A.
93.3
100
N.A.
93.3
N.A.
N.A.
73.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
12
0
78
12
0
0
0
0
0
0
12
% A
% Cys:
0
0
0
56
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
89
0
0
56
0
0
% E
% Phe:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
89
0
0
0
0
0
0
0
12
0
0
0
100
0
% G
% His:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
78
0
0
0
0
0
12
89
0
0
0
% L
% Met:
0
0
0
0
0
0
12
0
0
0
0
12
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
100
0
0
0
0
0
0
% P
% Gln:
0
0
0
12
0
0
0
0
0
0
89
0
23
0
12
% Q
% Arg:
0
0
0
0
0
0
0
12
0
0
0
0
12
0
0
% R
% Ser:
0
0
0
12
0
0
0
78
0
0
0
0
0
0
78
% S
% Thr:
0
0
89
12
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
89
0
12
0
12
0
12
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
89
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _